If you have trouble detoxing, or a variation in your genes (like the well-known C677T or A1298C mutations), it can lead to a less efficient version of the enzymes required for a successful detox.

This inefficiency can have a knock-on effect on the body's ability to process certain substances, including toxins.

So when you try to detox, you might experience adverse reactions include fatigue, headaches, and a generally feeling unwell. 

Genetic mutations also impact detox success because they can...

Decrease Nutrient Absorption and Utilisation

Genetic mutations can also affect how well the body absorbs and uses certain nutrients, like folate, which is vital for many bodily processes, including, you guessed it, detoxification.

Reduce Methylation

Methylation is like your body’s internal cleaning service. It helps in detoxifying homocysteine (a harmful amino acid) and converting it into other useful substances. With a less efficient MTHFR enzyme, the detox process can be less efficient, potentially leading to an accumulation of toxins and homocysteine.

Increase Sensitivity to Toxins and Medications

People with MTHFR variations can find themselves more sensitive to certain toxins and medications. This is because their bodies can struggle to process and eliminate these substances effectively.

So, what does this mean for someone with an MTHFR mutation or who has experienced issues with Detoxing in the past?

Well, it doesn't necessarily spell doom and gloom.

It's more about understanding your body's unique needs and adapting accordingly.

Tailored nutritional support, lifestyle modifications, and sometimes professional medical advice can help manage these challenges effectively.


Carolyn Ledowsky

Carolyn Ledowsky is the founder of MTHFR Support Australia. She is  also a naturopath, herbalist and nutritionist with a Bachelor of Herbal Medicine, Bachelor of Naturopathy, Advanced Diploma of Naturopathy and Diploma of Nutrition, also having studied courses in genetics at Duke University and The University of Maryland in the US. Carolyn is also a Health Scientist, researcher, and a results-oriented health expert who has the ability to provide straightforward and practical advice to address specific health issues, with a key focus on looking at how genes impact health and disease. 

This video is just one of the practical resources Carolyn loves to share with Patients like yourself, so that you can improve your health and stay informed with latest research.