MTHFR stands for Methylene-TetraHydroFolate Reductase
It is an enzyme that converts folate you eat into the active form (5-Methyltetrahydrofolate).

You can see from the pathway below that the folate you eat (DHF – dihydrofolate) has to be converted via many steps to the active folate 5-MTHFR.

The MTHFR enzyme affects this at the last step. So if you have a mutation in the gene then its going to be affecting how much active folate you have available.

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